HEALTHCARE APPLICATION
PLASMAIR for hospitals, clinics and ASSTs
Fully automatic 24/7 decontamination for critical healthcare environments. Designed for operating theatres, ISO-classified rooms, sterile preparation areas and controlled healthcare environments. Continuous environmental monitoring, ISO 14644-1:2022 compliance and validated bacterial load reduction above 95%.
Airborne multidrug‑resistant bacteria: MRSA, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, can survive in the air for hours. Traditional HEPA filters do not remove particles < 0.3 µm. Cold SDBD plasma does.
Traditional filtration captures contaminants.
PLASMAIR adds active microbial inactivation through cold SDBD plasma technology.
THE PROBLEM
Airborne pathogens in healthcare environments
Healthcare-associated infections (HAIs) remain one of the leading causes of hospital complications in Europe. Airborne microbial contamination is recognised as a major risk factor in operating theatres and controlled healthcare environments.
Airborne microorganisms may be transported through microparticles in the 0.1–0.5 μm range, one of the most difficult fractions for traditional mechanical filtration systems.
Multidrug-resistant bacteria — including MRSA, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii — represent a growing public health concern. These pathogens may survive for extended periods in air, on surfaces and within ventilation systems.
Mechanical filtration alone may not be sufficient in critical healthcare environments.
PLASMAIR integrates controlled cold SDBD plasma technology generating reactive oxygen and nitrogen species (ROS/RNS) for continuous microbial load reduction in air and on exposed surfaces. These reactive species contribute to microbial inactivation through oxidative stress mechanisms affecting bacterial cell membranes, proteins and viral surface structures.
During occupied daytime operation, the system maintains ozone concentrations within European exposure limits while continuously reducing microbial load.
| BACTERIUM AND RISK | INCIDENCE AND CONTEXT |
|---|---|
| Staphylococcus aureus (MRSA) - High | ~30% surgical infections |
| Klebsiella pneumoniae - High | ~10.4% HAI |
| Pseudomonas aeruginosa - High | ~8.1% HAI |
| Acinetobacter baumannii - Critical | Lethality 17–46% |
| Clostridioides difficile - High | ~12% HAI |
| Aspergillus spp. (spores) - High | Immunocompromised patients |
TARGET ENVIRONMENTS
Where PLASMAIR works in healthcare
Each healthcare environment has specific characteristics and regulatory requirements. PLASMAIR is configured and calibrated for each setting.
Operating rooms and surgical suites
Critical surgical environments. Decontamination between procedures during surgical downtime. Reduction of bacterial load before every procedure.
ISO 5– ISO7 – ISO8 class
- Intensive night‑time cycles and cycles between daytime procedures
- Monitoring of differential pressure between room and corridor
- Designed for ISO 5–8 classified healthcare environments
- Data logs for audits and clinical documentation
Nuclear medicine
Tightly confined environments that require continuous particulate and microbiological monitoring, and therefore daily, continuous decontamination.
Confined spaces
- Automatic continuous decontamination in limited‑access areas
- Protection for operators with long‑term exposure
- Reduction of environmental contamination exposure for operators
- Integration with dedicated ventilation systems
Obstetric and gynaecological theatres
Highly controlled contamination-sensitive environments
High-level contamination control
- Daily decontamination
- Adjustable daytime ozone setpoint: 0–50 ppb
- Reduction of allergens and VOCs in the environment
- Redundant presence sensors for maximum safety
High-risk healthcare departments
Areas where strict environmental control is essential and contamination risk is high (e.g. hospital pharmacy, sterile cytotoxic compounding labs, packaging zones, research laboratories, etc.).
24/7 monitoring
- Daily decontamination
- CO₂ and air quality control
- Reduction of bacterial load
- Remote monitoring for technical staff
TECHNICAL SPECIFICATIONS
PLASMAIR nameplate data
Performance
| System and installation
|
WHY CHOOSE PLASMAIR
System benefits
>95%
Microbiological decontamination
Reduction of bacteria, viruses, moulds and spores in air and on surfaces.
Validated through continuous 24/7 operation over 6 months.
−40%
Energy saving
Optimised recirculation reduces outdoor air volumes while maintaining ISO classification, reducing HVAC energy demand.
+100%
Filter lifetime
Plasma continuously decontaminates filters internally, extending their service life and reducing replacement frequency.
24/7
Continuous monitoring
All environmental parameters are continuously logged.
Historical data are available for ISO 14644-1:2022 audits and validation reports.
Zero
Seamless integration
Installed on the existing airflow lines, at the selected point. No structural changes to the environment.
2022
Patented technology
Protected by PoloPlasma patent technology.
STANDARDS AND COMPLIANCE
UNI EN ISO 14644-1:2022
The UNI EN ISO 14644‑1:2022 standard, in force since 2022, has updated and tightened requirements for cleanrooms and controlled environments in healthcare. PLASMAIR has been designed to meet, and exceed, all required parameters.
The standard defines air cleanliness classes based on particle concentration per cubic metre. Operating theatres generally require class ISO 5 (above the surgical field) and ISO 7/8 (for the room).
Multidrug‑resistant bacteria, MRSA, Klebsiella, Pseudomonas, Acinetobacter, are now a major public health emergency. They survive on surfaces and in the air for hours, days, weeks. Cleaning and mechanical filtration alone are not sufficient.
PLASMAIR acts where traditional systems stop: it generates reactive oxygen and nitrogen species (ROS/RNS) that, through oxidative stress mechanisms, inactivate bacterial cell membranes and viral receptors at ozone concentrations that are safe for staff.
Classe
ISO Class 5
Surgical field. Max 3,520 particles/m³ ≥ 0.5 µm. Highest standard.
Classe
ISO Class 7
General operating theatre. Max 352,000 particles/m³ ≥ 0.5 µm.
| REQUIRED PARAMETER | ISO REQUIREMENT | PLASMAIR |
|---|---|---|
| Microparticle count | ISO Class 5-7/8 | ✓ Exceeds ISO requirements |
| Microbiological contaminants | Active monitoring | ✓ 24/7 monitored |
| Filtration efficiency | F9 min. (EM ≥ 95%) | ✓ F9 + SDBD plasma |
| Integrated differential pressure sensor | Continuous control | ✓ Dedicated sensor |
| Temperature and humidity | Mandatory recording | ✓ Integrated datalogger |
| CO₂ – air quality | Monitoring | ✓ Integrated sensor |
| Audit documentation | Historical log required | ✓ Cloud-based data logging |
OPERATING MODES
Dual automatic operating modes
PlASMAIR automatically switches between occupied daytime operation and unoccupied intensive decontamination cycles
Normal decontamination
Target ozone
0-50 ppb
EU ozone health threshold
120 µg/m³ — ≤ 50 ppb (below EU health threshold)
Plasma action
Modulated, continuous
F9 filtration
Active 24/7
O₃ sensors
Redundant, automatic alarm
Result
ISO air quality maintenance
Intensive decontamination
Target ozone
400-600 ppb up to 240 min
Action
High-concentration plasma, air and surfaces
Safety
Presence sensors + door lock
Alarms
Visual and acoustic active
End of cycle
Automatic O₃ reduction
Result
Deep decontamination
OPERATING MODES
Ce.Me.Di. Turin tests — real‑world results
Validation protocol
- Initial “as found” sampling for 4 hours in operation — with staff working
- Activation of PLASMAIR for one week 24/7 under standard operating conditions
- Final sampling for 4 hours in operation — same conditions as initial test
- Ozone used as main indicator: 0 ppb by day, 400 ppb by night for 3 hours
- Particle measurements 0.5–5 µm at 7 sampling points across the room
- Continuous tests repeated for 6 consecutive months to verify reproducibility
PlASMAIR automatically switches between occupied daytime operation and unoccupied intensive decontamination cycles
ECONOMIC BENEFITS
Return on investment for hospital management
−85%
Microbiological load
Fewer HAI means fewer prolonged antibiotic therapies, fewer rehospitalisations and fewer post‑operative complications.
−40%
HVAC energy saving
Optimised 80/20 recirculation reduces outdoor air volumes and thermal loads, lowering system energy consumption.
+100%
Filter life
Plasma decontaminates filters from within, extending useful life and reducing replacement frequency and cost.
Zero
Routine intervention
Fully automatic system with remote monitoring. Technical staff intervene only for scheduled maintenance.
SAFETY
Active staff protection
Redundant O₃ sensors
Two independent ozone sensors continuously monitor ozone concentration.
Independent cross-check monitoring validates sensor readings in real time and enhances operational safety.
Automatic alarms are activated if the safety threshold is exceeded.
Alarm threshold: 60 ppb/m³
Presence sensors and door contacts
Detection of a person or door opening during the intensive cycle immediately stops the system and activates alarms.
Instant automatic shutdown
Visual and acoustic alarms
Light and sound signalling inside and outside the room during the intensive cycle.
“Accidental entry is actively prevented.”
Multimodal signalling
Automatic O₃ removal
At the end of the intensive cycle, the system automatically reduces ozone concentration before staff return.
Accidental entry is actively prevented.
Emergency access PPE
On request, we supply certified A1P2 gas masks for staff who may need to access the area in an emergency.
EN 140 · EN 143 · CE 2834
Ozone regulatory compliance
Daytime cycle is well below the EU threshold. Night‑time cycle is limited to unoccupied spaces with active physical and safety barriers.
EU 2008/50/EC compliant